ea0044p131 | Neoplasia, cancer and late effects | SFEBES2016
Dworakowska Dorota
, Szyszka Paulina
, Weitsman Gregory
, Diaz-Cano Salvador
, Korbonits Marta
, Grossman Ashley
, Bornstein Stefan
, Ng Tony
Introduction: Metformin is used as a first line treatment in type 2 diabetes. Several studies suggest that patients with type 2 diabetes treated with metformin may have reduced cancer risk. Recently it has been shown that Metformin acts directly on mitochondria to alter cellular bioenergetics and reduce tumorigenesis. We have shown that anti-proliferative effect of Mitotane is related with changes of expression of the genes involved in mitochondrial metabolism in human adrenoc...